Pretreatment with ultrasonication reduces the size of azelaic acid-chitosan nanoparticles prepared by electrospray

Authors

  • A. Amani Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • A. Hanafi Nanobiotechology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • M. H. Darvishi Nanobiotechology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • M. Kamali Nanobiotechology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract:

Nowadays, electrospray is becoming a favourable approach for preparing monodispersed nanoparticles. However, this approach is quite recent and requires further works to optimize control over physicochemical properties of its products. This study aimed to determine the possible effects of sonication as a pretreatment to reduce the size of azelaic acid-chitosan particle before using electrospray. The results showed that sonication treatment can produce submicron particles of azelaic acid-chitosan. By diluting the solution and increasing sonication time and amplitude, smaller particles were obtained with the smallest one at 516 nm, sized by dynamic light scattering. The pretreated solution was then electrosprayed to reduce the size of nanoparticles to 80 nm, indicating that sonication may play an important role in reducing the size of electrosprayed nanoparticles. The electrosprayed nanoparticles were nearly monodispersed and almost spherical in shape.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

control of the optical properties of nanoparticles by laser fields

در این پایان نامه، درهمتنیدگی بین یک سیستم نقطه کوانتومی دوگانه(مولکول نقطه کوانتومی) و میدان مورد مطالعه قرار گرفته است. از آنتروپی ون نیومن به عنوان ابزاری برای بررسی درهمتنیدگی بین اتم و میدان استفاده شده و تاثیر پارامترهای مختلف، نظیر تونل زنی(که توسط تغییر ولتاژ ایجاد می شود)، شدت میدان و نسبت دو گسیل خودبخودی بر رفتار درجه درهمتنیدگی سیستم بررسی شده اشت.با تغییر هر یک از این پارامترها، در...

15 صفحه اول

Ultrasonication of chitosan nanoparticle suspension : influence on particle size

Chitosan nanoparticles have been prepared using an ionic gelation method. The effects of freezedrying, cryoprotectant (D-trehalose) utilisation and ultrasonication time on the mean particle size, size distribution and stability of nanoparticles were investigated. The size distribution results indicated that freeze-drying caused the particles to agglomerate. Addition of the cryoprotectant and ul...

full text

Evaluation of loading efficiency of azelaic acid-chitosan particles using artificial neural networks

Objective(s): Chitosan, a biodegradable and cationic polysaccharide with increasing applications in biomedicine, possesses many advantages including mucoadhesivity, biocompatibility, and low-immunogenicity. The aim of this study, was investigating the influence of pH, ratio of azelaic acid/chitosan and molecular weight of chitosan on loading efficiency of azelaic acid in chitosan particles. Mat...

full text

THE METABOLISM OF AZELAIC ACID* BY H. GREGG SMITHt

The evidence concerning the utilization of dibasic fatty acids in the animal organism has been reviewed by Dakin (3) and more recently by Flaschentrager (4). Oxalic acid is burned to a limited extent, and in large amounts is toxic. Malonic and succinic acids are utilized, and glutaric acid is completely oxidized in the dog (3), but is nephrotoxic to the rabbit, while the higher acids affect the...

full text

study of cohesive devices in the textbook of english for the students of apsychology by rastegarpour

this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...

Nanoparticles Production from Glycerin via Electrospray and Size Measurement Techniques

Glycerin is a potential feedstock for hydrogen production because one mole of glycerin can produce up to four moles of hydrogen. In addition to glycerin, several potential biorenewable feedstocks, such as triglycerides and their derivatives, could be used for hydrogen production. The major challenge in using such feedstocks in a hydrogen-producing reformer is atomizing these viscous feedstocks ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 73  issue 1

pages  53- 59

publication date 2018-03-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023