Preparation and physicochemical evaluation of topical formulations of purified curcuminoids from Curcuma longa rhizome
Authors
Abstract:
Background and objectives: The purpose of this study was optimization of semisolid topical formulation from ethanol extract of turmeric and evaluation of rheological characterization and investigation of physicochemical control tests. Methods: The ethanolic extract was prepared with Soxhlet method and the compounds were isolated with silica gel column chromatography. Isolation of curcuminoids was accomplished by preparative HPLC. The accelerated and real time stability tests for the formulations were investigated at 40±2 °C/70% RH for 90 days and 30±2° C/35%±5 RH for 12 month, respectively. Results: The yield of pure curcuminoids was 0.8%.The results of rheograms at 25° C showed pseudoplastic, plastic and pseudoplastic behavior for the ointment, cream and gel formulations respectively. The pH was measured by using a digital type of pH meter by dipping the glass electrical probe for all of formulation, and the consequences exhibited PH values of 6.6, 6.8 and 6.9for the ointment, cream and gel, respectively. The results of cumulative release (µg/cm2) for ointment, cream and gel formulation achieved with dissolution media which contained buffer phosphate with pH 7.2 and 1% tween 20 after 24 h were 693.6, 648.5 and 650.5, respectively. Discussion: The advantage of this method extraction compared to previously described methods, was utilizing safer solvent for extraction. The cumulative release of formulation and drug content during the physicochemical control tests was compared with commercial product and showed no significant different (p˃ 0.05).The formulations of this study showed functional and physical stability in the period of the study.
similar resources
Pharmacognostic, phytochemical and physicochemical studies of CURCUMA LONGA linn. rhizome
In recent year there has been rapid increase in the standardization of selected medicinal plant of potential therapeutic significance. Despite the morden techniques, identification of plant drug by Pharmacognostic study is more reliable. The rhizomes of Curcuma longa reported to have good medicinal values in traditional system of medicines. The present study deals with pharmacognostic parameter...
full textStudies on antifertility effect of rhizome of curcuma longa linn
Turmeric is used as a condiment and also as a herbal medicine in different kinds of illness. It is used by tribes as an antifertility and aborcifacient agent for a long period in different parts of India. Because of scarcity of research data regarding the effectiveness and mode of action of curcumin, the active principle present in turmeric, we undertake this research work to evaluate its antif...
full textComparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract of Curcuma longa
Curcuma longa is widely known for its anti-inflammatory activity in traditional system of medicine for centuries and has been scientifically validated extensively. The present study was conducted to evaluate the anti-inflammatory activity of curcuminoids and oil-free aqueous extract (COFAE) of C. longa and compare it with that of curcuminoids and turmerones (volatile oil), the bioactive compone...
full textextraction and acetylation of purified trypsin from bovin pancreas and study of some its physico-chemical properties
آنزیم تریپسین در شرایط قلیایی ناپایدار می باشد .و فعالیت پروتئولیتیکی تریپسین منجربه خود هضمی آن در جایگاههای خاصی می گردد. بنابر این آنزیمی با ناپایداری بالا محسوب میگردد. در سالهای اخیر موفق شدند که با ایجاد تغیرات شیمیایی با اضافه کردن فلزات خاص ، کلسیم و یا عمل استیلاسیون منجر به افزایش پایداری آنزیم تریپسین گردند. مطالعات در حال حاضر نشان می دهد که تریپسین استیله شده فعالیت آنزیمی خود را ...
15 صفحه اولEvaluation of antimicrobial activity of Curcuma longa rhizome extract against Staphylococcus aureus☆
The in vitro antimicrobial activity of different fractions obtained from rhizome of Curcuma longa was investigated against standard strain and clinical isolates of Staphylococcus aureus. The clinical isolates were found more sensitive for different fractions, than the standard strain of S. aureus. Scanning electron microscopic observations revealed that test pathogen treated with C. longa extra...
full textMy Resources
Journal title
volume 4 issue Supplement
pages 8- 8
publication date 2017-11-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023