PREPARATION AND OPTIMISATIONOF PALM-BASED LIPID NANOPARTICLES LOADED WITH GRISEOFULVIN
Authors
Abstract:
Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by hot homogenisation and a solvent-free method. The optimum griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, such as high pressure homogenisation (HPH) parameters, lipid and surfactant screening and selection of suitable lipid to surfactant ratios; followed by photon correlation study. A HPLC method has also been validated for the drug loading capacity study. The optimum HPH parameter was determined to be 1500 bar with 5 cycles and among the lipid based materials; Lipid C (triglycerides) was selected for the preparation of lipid nanoparticles. Tween 80 was chosenfrom the Tween series surfactantsfor its highest saturated solubility of griseofulvinat 53.1 ± 2.16 µg/mL. The optimum formulation of the griseofulvin loaded lipid demonstrated nano range particle size (179.8 nm) withintermediate distribution index (PDI) of 0.306, zeta potential of -27.9 mV and drug loading of 0.77%. The formulation was stable upon storage for 1 month at room temperature (25ºC) and higher temperature (45ºC) with consistent drug loading capacity.
similar resources
Preparation and Optimization OF Palm-Based Lipid Nanoparticles Loaded with Griseofulvin
Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by solvent-free hot homogenization method. The griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, by altering the high pressure homogenisation (HPH) parameters, screening on palm-based lipids and Tween series surfactants and selection of lipid to surfactant ratios. A HPLC method has be...
full textPreparation and characterization of solid lipid nanoparticles loaded with doxorubicin.
Solid lipid nanoparticles (SLN) loaded with doxorubicin were prepared by solvent emulsification-diffusion method. Glyceryl caprate (Capmul)MCM C10) was used as lipid core, and curdlan as the shell material. Dimethyl sulfoxide (DMSO) was used to dissolve both lipid and drug. Polyethylene glycol 660 hydroxystearate (Solutol)HS15) was employed as surfactant. Major formulation parameters were optim...
full textPreparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles
Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- and gastrointestinal-related side effects. Nanoformulation of drugs in an appropriate drug carrier system has been extensively studied and shown to have the potential to i...
full textPreparation and Evaluation of Montelukast Sodium Loaded Solid Lipid Nanoparticles
Solid lipid nanoparticles (SLNs) are an alternative carrier system used to load the drug for targeting, to improve the bioavailability by increasing its solubility, and protecting the drug from presystemic metabolism. The avoidance of presystemic metabolism is due to the nano-metric size range, so that the liver cannot uptake the drug from the delivery system and is not metabolized by the liver...
full textMy Resources
Journal title
volume 16 issue 2
pages 451- 461
publication date 2017-06-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023