Preparation and labeling of HMPAO kit in Iran [Persian]
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Abstract:
In recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rCBF) such as 75Se labelled PIPSE and MOSE, ²º¹TI labelled DDC and 99mTc labelled HMPAO. HMPAO with two asymmetric carbon atoms (At the 3 and 9 positions), produces d,1 and meso isomers, only one of which is retained in the brain. Rapid intracellular conversion of 99mTc-d,1-HMPAO to hydrophilic 99mTC species causes the complex becoming fixed in the brain. In this report we synthesized and characterized d,1-HMPAO. Kit formulations have been done and biological characteristics of 99mTc-d,1-HMPAO have been examined.
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Journal title
volume 8 issue 1
pages 27- 42
publication date 2000-12-01
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