Preparation and characterization of friendly colloidal Hydroxyapatite based on natural Milk’s casein

Authors

  • Ali akbar sajjadi Institute of Water & Energy, Sharif University of Technology P. O. Box 11155/8639, Tehran, Iran.
  • Babak Sadeghi Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
  • Nazanin Farhadyar Department of Chemistry, Veramin Branch, Islamic Azad University, Veramin, Iran.
  • Reyhaneh Sahba Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Abstract:

Biocompatible hydroxyapatite nanocomposites are biocompatible, biodegradable and nontoxic have been paid many attentions as one of the most suitable vehicle for drug delivery use. Our objective in this work was to prepare and characterize caseins based HA nanocomposite in a colloidal form for drug delivery purposes. Casein biopolymer was firstly extracted from skimmed milk by adding acetic acid and was used then to prepare colloidal hydroxyapatite nanoparticles (nHA) through a modified microemulsion technique. Characterization of the as prepared samples was carried out by means of Fourier Transform Infrared (FT-IR) spectroscopy, X-ray powder diffraction patterns (XRD), Field Emission Scanning and Transmission Microscopy (FESEM & TEM).  Dynamic light scattering (DLS) technique was finally used to measure particle size and zeta potential distribution of the sample using electrophoresis mobility. The results revealed successful preparation of a colloidal HA /casein suspension with a hydrodynamic zeta average particle size distribution of 256.6 nm.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Preparation and characterization of fluorinated porcine hydroxyapatite.

Simple chemical and thermal treatments were applied to prepare fluorinated porcine hydroxyapatite (FPHA). Morphology of FPHA was observed using SEM. Physiochemical characteristics, namely crystalline phase, chemical composition, functional groups, and binding energy of fluorine were investigated using XRD, EDX, FTIR, and XPS respectively. Concentration of free fluoride ion released from FPHA in...

full text

Preparation and Characterization of Colloidal Silica in Alkaline and Constant Range of pH

In this study, alkaline colloidal silica was prepared by titration of an alkaline solution such as sodium silicate with silicic acid in constant range of pH  .This constant range of pH was achieved by using concentrated soduim silicate solutions as pH adjusting solutions during titration.The sodium silicate solutions  having a variety of...

full text

Preparation and characterization of Curcumin niosomal nanoparticles via a simple and eco-friendly route

In this investigation, curcumin niosomal nanoparticles were prepared via a simple, efficient and eco-friendly route, thin film hydration (TFH), in the presence of different mixture of the surfactants (tween 60 and span 60). Cholesterol ratio to surfactant, as effective factor, was altered to obtain the optimal nanoparticles. The size, zeta potential, size distribution, entrapment efficiency of ...

full text

Preparation and Characterization of Hydroxyapatite Coating on Ti6Al4V Cylinders by Combination of Alkali-Heat Treatments and Biomimetic Method

Biomimetic method was used to apply hydroxyapatite (HA) coating onto Ti6Al4V cylinders. This process is a physicochemical method in which a substrate is soaked in a solution simulating the physiological conditions, for a period of time enough to form a desirable layer of the calcium phosphate on the substrate. In the present study, specimens were soaked in 5, 10 M solutions of NaOH at temperatu...

full text

Preparation and Characterization of Porous Blocks of Synthetic Hydroxyapatite

−− Porous structures were conformed by pressing and heating of hydroxyapatite powders. Samples were obtained in the form of blocks with 47 % porosity. An interval of pore sizes interconnected among 50-120 μm was obtained. The diametrile tensile stress of evaluated samples oscillated between 4 and 21 MPa, according to what has been reported for porous ceramics. The diffraction studies of x-ray o...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 9  issue 3

pages  238- 245

publication date 2018-08-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023