Prenatal exposure to TAK242 affects the childhood autism in offspring in animal models of autism spectrum disorder

Authors

  • De Wu The Children’s Neurorehabilitation Center, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, Anhui, China
  • Jing Li The Children’s Neurorehabilitation Center, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, Anhui, China
  • Jing Zhu The Children’s Neurorehabilitation Center, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, Anhui, China
  • Jiulai Tang The Children’s Neurorehabilitation Center, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, Anhui, China
  • Shu Hou Department of Pediatrics, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, Anhui, China
  • Xiaoyan Xu The Children’s Neurorehabilitation Center, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, Anhui, China
Abstract:

Objective(s): To evaluate whether prenatal exposure to TAK242 affects childhood autism in the offspring in animal models of autism spectrum disorder (ASD). Materials and Methods:The pregnant rats were pseudo-randomly divided into three groups, the ASD model group, the TAK242 treatment group, and the control group. The ASD model was constructed by injecting IP with LPS. The blood samples from 1-month-old offspring were collected for cytokine evaluation and the social interaction test was used in the offspring of ASD rats. Rats were killed and the hippocampus, cerebral cortex, and cerebellum were used for the immunohistochemical study. Results: As compared to the control, the levels of IFN-γ, IL-1β, IL-2, and IL-6 were significantly increased (P

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Journal title

volume 20  issue 9

pages  1016- 1020

publication date 2017-09-01

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