Photodynamic therapy (PDT)
Authors
Abstract:
Photodynamic therapy (PDT) is a comparatively novel therapeutic method involving a safe light source and a light-sensitive substance, termed as photosensitizers (PSs), such as methylene blue (MB), toluidine blue (TBO), sulfonated aluminum phthalocyanine, chlorine derivatives, nontoxic indocyanine green (ICG), and curcumin (CUR). (1) The combination of a nontoxic PS with low-intensity visible light in the presence of oxygen develops reactive oxygen species (ROS) that are toxic and can cause oxidative damage to microorganisms and tumor cells. (2-4) PSs do not induce cytotoxicity but are activated by laser irradiation at a proper wavelength and develop ROS. (5,6)
similar resources
Photodynamic Therapy (PDT): PDT Mechanisms
Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how t...
full textAnimal models for photodynamic therapy (PDT).
Photodynamic therapy (PDT) employs non-toxic dyes called photosensitizers (PSs), which absorb visible light to give the excited singlet state, followed by the long-lived triplet state that can undergo photochemistry. In the presence of ambient oxygen, reactive oxygen species (ROS), such as singlet oxygen and hydroxyl radicals are formed that are able to kill cancer cells, inactivate microbial p...
full textA method for video-assisted thoracoscopic photodynamic therapy (VAT-PDT).
A technique is described for application of photodynamic therapy (PDT) to peripheral pulmonary and other intrathoracic malignant tumours. For video-assisted thoracoscopic-PDT we advocate the use of the flexible fibreoptic bronchoscope through an appropriately placed port. This, together with the standard thoracoscope and attached monitor can provide three-dimensional visualisation of the intrat...
full text[Use of nanoparticles (NP) in photodynamic therapy (PDT) against cancer].
Nanotechnology is a promising interdisciplinary field for developing improved methods of diagnosis and treatment of different diseases, including cancer. Give their optical, magnetic, and structural property, the nanoparticles have been proposed to be use in the development of unconventional treatments for cancer such as photodynamic therapy (PDT). In PDT, a photosensitizing agent is used that ...
full textPhotodynamic therapy (PDT) of cancer: from local to systemic treatment.
Photodynamic therapy (PDT) requires a medical device, a photosensitizing drug and adequate use of both to trigger biological mechanisms that can rapidly destroy the primary tumour and provide long-lasting protection against metastasis. We present a multidisciplinary view of the issues raised by the development of PDT. We show how spectroscopy, photophysics, photochemistry and pharmacokinetics o...
full textHypericin-photodynamic therapy (PDT) using an alternative treatment regime suitable for multi-fraction PDT.
Photodynamic therapy (PDT) outcome depends on the conditions under which it is carried out. Maintaining the tumour tissue oxygen level is important for PDT efficacy and using a low fluence rate can improve outcome. In this work we studied the response of human nasopharyngeal carcinoma tumours in murine models to hypericin-PDT carried out under low fluence and fluence rate. A drug-light interval...
full textMy Resources
Journal title
volume 6 issue 1
pages 1- 3
publication date 2021-01
By following a journal you will be notified via email when a new issue of this journal is published.
No Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023