Pharmacokinetics of Cefepime Following Intravenous and Intramuscular Administration in Sheep

Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Pharmacokinetics of cefepime was studied following single dose intravenous and intramuscular administration at the dose of 20 mg/kg of body weight in sheep. Drug concentration in serum was determined using high performance liquid chromatography (HPLC). Following single dose intravenous administration, the drug was rapidly distributed (t 1/2 a : 0.20 ± 0.02 h) and eliminated (t 1/2 b : 2.54 ± 0.12 h) from the body. The area under curve (AUC 0- ¥ ) was 135.50 ± 5.63 m g h/mL. The drug was cleared at the rate of 2.48 ± 0.09 mL/min/kg with mean residence time (MRT) of 2.84 ± 0.13 h. Following IM administration, the drug was rapidly absorbed (C max : 26.34 ± 1.44 m g/mL; t max : 0.75 h) and slowly eliminated (t 1/2 b : 5.17 ± 0.44 h) from body. The volume of distribution at steady state (Vd ss ), area under curve (AUC), total body clearance (Cl B ) and mean residence time (MRT) were 1.11 ± 0.10 L/kg, 140.90 ± 8.67 m g h/mL, 0.15 ± 0.01 mL/min/kg and 6.89 ± 1.0 h, respectively. The bioavailability of cefepime following intramuscular administration was 103 ± 8.0 %.