Performance of methylation and expression fluctuations of sonic hedgehog genes in gastric adenocarcinoma

Gastric cancer (GC) is considered as one of the most serious cancers, and in Iran, due to environmental factors in different regions, it has a high frequency. Apart from environmental factors, genetic and epigenetic ones also play a key role in the development of carcinogenesis of GC. In this regard, the study of functioning of the molecular mechanisms involved in the carcinogenesis and also tumorigenesis of this malignancy in different molecular pathways   to identify applied biomarkers in early diagnosis is of great importance. Thus, molecular pathways like sonic hedgehog  (SHH) may interfere with this type of cancer. In this review, it has attempted to investigate the performance of the fluctuations of these important genes in SHH pathway.