Papaver Rhoeas L. Hydroalcoholic Extract Exacerbates Forced Swimming Test-Induced Depression in Mice

Authors

  • Akram Najafi-Abedi Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Farshid Javid Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Fatemeh Jafari Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Hedayat Sahraei Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Mina Ranjbaran Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Mohammad Rahimzadeh-Behzadi Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Mohammad-Reza Memar-Jafari Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Mohsen Pirpiran Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Naser Osanloo Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
  • Seyed Ali Mousavi-Khosravi Neuroscience Research Center, Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran.
Abstract:

Introduction: Depression is one of the most frequent psychiatric disorders in the world with occurs with higher incidence in women. In the present study, the effect of water-alcoholic extract of Papaver rhoeas L. on forced swimming test (FST) in Swiss-Webster mice were examined. Methods: We used Swiss-Webster mice (20-25 g) to execute FST on them. The plant extract (1, 10, 30, and 100 mg/kg) was injected to the animals 30 minutes before each session. Fluoxetine (20 mg/kg) was used as standard antidepressant drug. In another group of animals, 30 minutes after extract administration, blood samples were taken from retro-orbital sinus for corticosterone assay. Yet in third group, the drugs were injected to the animals and 30 minutes later, their activities were tested in an open field apparatus. Results: Our experiments showed that the extract efficiently reduced FST time both in male and female mice dose-dependently. This effect was comparable with fluoxetine. In addition, corticosterone assay indicated that plasma corticosterone in animals which received extract was higher than those amounts in fluoxetine and saline controls. Moreover, the animals did not show any motor activity deficit in all doses of the extract and fluoxetine compared to saline control. Conclusion: The extract of Papaver rhoeas can reduce immobility time which is comparable to the effect of fluoxetine. Also the effect of the extract is contrary to its effects on plasma corticosterone level and or animals’ activity.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

papaver rhoeas l. hydroalcoholic extract exacerbates forced swimming test-induced depression in mice

introduction: depression is one of the most frequent psychiatric disorders in the world with occurs with higher incidence in women. in the present study, the effect of water-alcoholic extract of papaver rhoeas l. on forced swimming test (fst) in swiss-webster mice were examined. methods: we used swiss-webster mice (20-25 g) to execute fst on them. the plant extract (1, 10, 30, and 100 mg/kg) wa...

full text

Antigenotoxic Capacity of Papaver Rhoeas L

Application of exogenic bioactive natural plant compounds with protective, anti-mutagenic and anti-genotoxic effects against various chemical and physical agents is one of the modern approaches for reduction of the mutagenic burden of cells. Objective: The present study aims to provide data on the cytoxic and genotoxic effects of Papaver rhoeas L. water leaf extract and its anti-cytotoxic and a...

full text

Antidepressant Effect of Cinnamon (Cinnamomum zeylanicum L.) Water Extract (CWE) Evaluated by Forced Swimming Test in Mice

Background: Few studies have been done considering the effectiveness of aqueous extract of cinnamon in neurological diseases. In previous studies, reducing the pain of hydro-alcoholic cinnamon extract in the second phase (chronic) of the formalin test and reduction of inflammation in animal models as well as in humans following cinnamon administration have been emphasized. There are also studie...

full text

Antidepressant Effects of a Hydroalcoholic Extract of Rosa Canina L. on the Depression inDuced by Reserpine in Balb/c mice

Background: Recent studies have shown that oxidative stress is a major cause of depression. Rosa canina L. is a fruit that contains different antioxidant compounds. The present study was conducted to investigate the antidepressant effects of a hydroalcoholic extract of Rosa canina L. on male mice using the behavioral tests of forced swim test (FST) and tail suspension test (TST). Materials and ...

full text

Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice

Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. Howeve...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 7  issue 3

pages  195- 202

publication date 2016-07

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023