P7: Valproic Acid Mediated Neuroprotection and Neurogenesis after Acute Spinal Cord Injury
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p7: valproic acid mediated neuroprotection and neurogenesis after acute spinal cord injury
spinal cord injury (sci)-induced systemic inflammatory response affects multiple organs outside the spinal cord. treatment options for such complications are lacking. valproic acid (vpa) is a histone deacetylase inhibitor, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. acetylation of histones is critical to...
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Introduction: Spinal cord injury (SCI) following traumatic events is associated with the limited therapeutic options and sever complications, which can be partly due to inflammatory response. Therefore, this study aims to explore the role of inflammation in spinal cord injury. The findings showed that the pathological conditions of nervous system lead to activation of microglia, astrocyte, neut...
full textThe Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury
OBJECTIVE Valproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and functional recovery from spinal cord injury (SCI) associated with VPA treatment in a rat model. METHODS Locomotor function was assessed according to the Basso-Beattie-Bresnahan scale for 2 weeks in rats after receiving twice daily intraper...
full textNeuroprotection and enhanced recovery with edaravone after acute spinal cord injury in rats.
STUDY DESIGN The effect of edaravone, a novel free radical scavenger, was assessed functionally and histologically using a rat spinal cord contusion model. OBJECTIVE To investigate the effect of edaravone on neuroprotection after spinal cord injury in rats. SUMMARY OF BACKGROUND DATA The spinal cord injury results in immediate physical damage (primary injury), followed by a prolonged neural...
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Journal title
volume 3 issue 4
pages 34- 34
publication date 2015-12
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