P60: Laminin Based Tissue Engineering for Central Nervous System Regeneration

Materials for Central Nervous System Tissue Engineering

Chitin-based tubes for tissue engineering in the nervous system.

The purpose of this study was to investigate chitin and chitosan as potential materials for biodegradable nerve guides. Transparent chitin hydrogel tubes were synthesized, for the first time, from chitosan solutions using acylation chemistry and mold casting techniques. Alkaline hydrolysis of chitin tubes resulted in chitosan tubes, with the extent of hydrolysis controlling the resulting amine ...

Central nervous system regeneration--where are we?

Until relatively recently, we thought that the human central nervous system (CNS) was unable to regenerate. However, with the initial discovery of remyelination within the brain and the spinal cord in cat (Bunge, Bunge and Ris. Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord. J Biophys Biochem Cytol 1961;10:67-94.) and later in human (Prineas and Connel...

Current concepts in central nervous system regeneration.

A dictum long-held has stated that the adult mammalian brain and spinal cord are not capable of regeneration after injury. Recent discoveries have, however, challenged this dogma. In particular, a more complete understanding of developmental neurobiology has provided an insight into possible ways in which neuronal regeneration in the central nervous system may be encouraged. Knowledge of the ro...

Regeneration in the central nervous system.

Unlike neonatal axons, mammalian adult axons of the CNS do not regenerate after injury. This developmental loss of regenerative capacity, is correlated with the onset of myelination. Likewise, myelin, or myelin-associated components such as Nogo-A and myelin-associated glycoprotein (MAG) inhibit regeneration from older but not younger neurons. Identification of the molecular events responsible ...

Regeneration of the adult central nervous system

Cloned mammals have bred naturally for the first time, researchers reported last month, but faced the most trying of times. Two endangered African wildcat clones have each given birth to a litter, a total of eight kittens in all. The first five kittens were born on July 26 to Madge, a clone of the wildcat Nancy. The second litter, consisting of three kittens, was born on August 2 to Caty, also ...