P-41: Evaluation of CAPZA3 Expression in Infertile Individuals Undergoing Intracytoplasmic Sperm Injection

Authors

  • Ghaedi K
  • Javadi GR
  • Tanhaee S
  • Tavalaee M
Abstract:

Background: CAPZA3 is one of the actin-capping proteins believed to be play an important role in controlling of actin polymerization during spermiogenesis and has been shown to be peresent in mature sperm. Immunohistochemistry showed that human CAPZA3 is localized in the neck region of ejaculated sperm, with moderate and faint signals also detected in the tail and post-acrosome region respectively. For the first time, we evaluated correlation between CAPZA3 expression and fertilization rate in infertile men undergoing ICSI (intracytoplasmic sperm injection). Materials and Methods: We have measured the expression of CAPZA3 in 25 infertile men candidate ICSI with realtime PCR technique. Results: We observed a significant correlation between CAPZA3 expression and fertilization rate in these infertile men. Conclusion: CAPZA3 may play a physiologically role in sperm construction and fertility in human.

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Journal title

volume 6  issue 2

pages  -

publication date 2012-09-01

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