P-224: Chlropromazine-Induced Hyperprolactinemia on Rat
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Chlorpromazine-Induced Hyperprolactinemia on Rat’s Uterus
Background: Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in rats. Moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. Methods: Albino Wistar r...
full textChlorpromazine-Induced Hyperprolactinemia on Rat’s Uterus
BACKGROUND Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in rats. Moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. METHODS Albino Wistar r...
full textAntipsychotic-induced hyperprolactinemia.
Use of antipsychotic agents has been associated with hyperprolactinemia, or elevated prolactin levels; this hormonal abnormality can interfere with the functioning of reproductive, endocrine, and metabolic systems. As antipsychotic agents are increasingly used for both United States Food and Drug Administration-approved and nonapproved indications, many individuals are at risk for developing an...
full textchlorpromazine-induced hyperprolactinemia on rat’s uterus
background: hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. the current study was designed to evaluate dose-dependent effect of chlorpromazine (cpz) on hormonal changes and uterine horn histological structure in rats. moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. methods: albino wistar r...
full textAripiprazole reverses paliperidone-induced hyperprolactinemia.
Hyperprolactinemia is a common side effect of antipsychotic treatments. Existing alternatives to resolve this problem include decreasing the antipsychotic dose or switching to a different antipsychotic agent. Nevertheless, said modifications can sometimes lead to decompensation of the patient. We report a clinical case of a female patient in whom the combined treatment of 5 mg/day of aripiprazo...
full textAntipsychotic-induced Hyperprolactinemia: Pathophysiology and Clinical Consequences
Hyperprolactinemia is one of the major adverse effects of antipsychotic agents. Although it is predominantly associated with the use of conventional or typical agents, atypical agents also cause varying degrees of hyperprolactinemia. Clinical manifestations, which tend to be underrecognized, are the result of the direct action of prolactin on its target tissues and of the sequelae of hypogonadi...
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volume 8 issue 2.5
pages 234- 234
publication date 2014-07-01
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