P-188: Mammary Gland Changes during Chlorpromazine Treatment in Female Rats

Background: Antipsychotic drugs are medications used to treat schizophrenia and other psychotic disorders. Antipsychotic drugs can cause unwanted side effects. Hyperprolactinemia is an important but neglected adverse effect. The aim of the this study was to consider the effects of Chlropromazine -induced hyperprolactinaemia on mammary glands of female rats . Materials and Methods: In this study 32 adult female wistar rats (160 ± 5 g) were randomly divided into four groups (n=8 each) with one group serving as control sham((5 mL/kg of 0.5% methylcellulose solution.), in the drug treated groups female rats were orally administered CPZ (3, 10, 30 mg/kg) once daily for 28 days .The test compound was suspended in 0.5% methylcellulose solution . On day 29th all rats were sacrificed by CO2 inhalation and blood samples were collected for biochemicals analyses. The mammary glands were removed surgically and prepared for histological study. Results: This study showed that treated by CPZ had significant increase in prolactin level in plasma . In the mammary gland, acinous hyperplasia with an increased secretion was observed in females treated with CPZ. Conclusion: These results showed that CPZ-induced hyperprolactinaemia negatively affects on mammary glands and there were mammary gland changes and unexpected breast development.