One-pot Synthesis of Polysubstituted Indolizine Derivatives

Authors

  • Ashraf Sadat Shahvelayati
  • Hassan Saydi
  • Mohammad Piltan
  • Seyed Amir Zarei
Abstract:

An efficient approach to the synthesis of 1,2,3-trisubstituted indolizines is described via one-pot reactions of pyridine and dialkyl acetylendicarboxylate in the presence of ethyl 2-chloroacetoacetate in MeOH at room temperature. The corresponding 1, 2, 3-trisubstituted indolizines may be useful building blocks for the construction of complex indolizine derivatives.

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Journal title

volume 10  issue 3

pages  85- 90

publication date 2016-08-01

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