One-Pot Synthesis of Phenytoin Analogs in soilution Conditions
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Abstract:
phenytoine derivatives were synthesized , via the pinacol condensation with thereaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thioureain presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle atroom temperatures. The reaction was completed at short reaction times (approximately15min) and pure products were obtained with high yields (81-94%).
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Journal title
volume 3 issue 2
pages 53- 62
publication date 2013-06-01
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