Observation of squamous cell carcinoma in a goat flock in Iran

Squamous cell carcinoma (SCC) is a tumor consisting of squamous epithelial cells. This tumor is relatively uncommon in goats. In this report, we discuss clinical, gross and histopathological features of SCC in six goats. The goats were referred to the veterinary clinic with a progressive ulcerative and hemorrhagic mass located in the perineal area. The vital signs (temperature, pulse rate, respiration rate) were normal. Biopsy specimens were taken and histopathological examinations were done. The tumor cells were large and had an abundant eosinophilic cytoplasm, ovoid nuclei with a prominent nucleolus. Keratin tonofibers and keratin pearls were also seen. The mitotic figures were moderate. The mass was found to be a moderately differentiated SCC. Ulceration with infiltration of neutrophils was observed on the surface of the tumors. The SCC tumors are uncommon in goats and have multi-factorial etiology. Age, ultraviolet (UV) light exposure, lack of epidermis pigmentation, and viruses may be involved in the presence of SCC.