O-6: Response to Potassium Paraaminobenzoate(PotabaTM) or Iontophoresis with Verapamiland Dexamethasone (Physion TM) inPeyronie

Structured Self-Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie's Disease

Introduction. New therapies evolve for the treatment of Peyronie's disease (PD) including the application of dexamethasone and verapamil using Electro Motive Drug Administration (EMDA). Patients and Methods. Patients with PD were routinely offered Potaba, Vitamin E, tamoxifen or colchicine for 6 to 18 months and for those with no improvement, 18 applications of dexamethasone and verapamil using...

In vitro optimization of dexamethasone phosphate delivery by iontophoresis.

BACKGROUND AND PURPOSE This study was designed to evaluate the effects of competing ions and electroosmosis on the transdermal iontophoresis of dexamethasone phosphate (Dex-Phos) and to identify the optimal conditions for its delivery. METHODS The experiments were performed using pig skin, in side-by-side diffusion cells (0.78 cm(2)), passing a constant current of 0.3 mA via Ag-AgCl electrode...

Transdermal iontophoresis with verapamil and dexamethasone in the acute phase of peyronie's disease. Our experience.

OBJECTIVES To evaluate the treatment of Peyronie's disease (PD) with verapamil and dexamethasone iontophoresis. METHODS Twenty nine patients with PD were treated by means of a Miniphysionize" dispositive 3 sessions a week during 4 consecutive weeks. 5mL of a combination of verapamil(10mg.) and dexamethasone (4mg.) were transdermally administered with a 2.5 mA current during 20 min. The aim ...

Eating or Feeding Our Young: A Response to Recent Commentaries

Response of Broiler Chickens to Quantitative Feed Restriction with or without Ascorbic Acid Supplementation

Ascorbic acid (vitamin C) supplementation has been documented as a useful tool to improve the performance of laying birds reared under harsh environmental conditions. However, there is limited information on the use of ascorbic acid as a means of ameliorating the stressful conditions imposed by feed restriction. To this effect a 3 × 2 factorial experiment was carried out to evaluate the effect ...

Relation of plasma dexamethasone to clinical response.

OBJECTIVE The clinical effects of high dosage pulse glucocorticosteroid (GS) infusion as a treatment for rheumatoid arthritis (RA) differ considerably between patients. The aim of the present study was to gain more insight into these differences in clinical response. METHODS Twenty-three RA patients (6 M/17 F) with treatment-resistant active erosive disease were treated with GS pulse therapy,...