O-37: Effect of Weight Reduction on OvarianFunctions in Anovulatory Overweight Womenwith Polycystic Ovaries

Background: The prevalence of obesity is continuing to increase among women. Irregular menstrual cycles, reduced spontaneous and assisted fertility and an increased risk of miscarriage are risks associated with obesity that are often overlooked . This prospective study evaluated the effect of weight reduction on ovarian functions and fertility in anovulatory overweight women with polycystic ovary syndrome (PCOS). Materials and Methods: Forty one anovulatory overweight women (BMI > 24.9 - 30) with PCOS were enrolled in the study. All had chronic anovulation and first or second infertility. Thirty four of them were oligo-amenorrhoeic. Their partners were normospermic.they had not tubal factor or other female factors. For all women diet and exercise was recommended. Ovarian imaging and parameters and fertility rate were assessed at baseline and after weight loss of 5 and 10%. Results: Twenty nine patients (70.7%) lost at least 5% of their body weight. nine of these patients (21.9%) reached a 10% decrease in weight. Ovarian morphology changed during the diet (we observed a significant reduction in ovarian volume and in the number of microfollicles per ovary). Among the 34 patients with oligoamenorrhoea, 21(61.8%) had a resumption of regular cycles and 14 ( 41.2%) experienced spontaneous ovulation. All spontaneous pregnancies occurred in womenwho lost at least 5% of their weight. and 9 women were in group with10% decrease in weight . Conclusion: Weight loss through a controlled diet improves ovarian function (restore ovulatory cycles) and morphology (volume and microfollicle number). Also can allowing spontaneous pregnancy in overweight PCOS women.