O-10: PLAP Marker in Testicular Biopsy ofIranian Men by Immunohistochemistry Methodfor Early Diagnosis of Testicular Carcinomain Situ

Background: Testicular Carcinoma in situ (CIS), also known as intratubular germ cell neoplasia (ITGCN), is a pre-invasive precursor of testicular germ cell tumours (TCGTs), i.e seminomas and non-seminomas -the commonest cancer type of male adolescents and young adults- which can be diagnosed using a surgical biopsy. Infertility is one of the condition known to predispose to TGCT, but based on scarce existing data, the prevalence of CIS in this risk group was estimated approximately 1% (in range of 0-3.5%) in 15-35 year men in the world. In this study, we investigated the prevalence of CIS based on testicular biopsies performed for infertility reasons in group of males in Avicenna Research Institute. Materials and Methods: There were 722 biopsies during 1386-1388 evaluated morphologically then 88 of cases were evaluated by immunohistochemistry for placental -like alkaline phosphatase (PLAP) -the known estabilashed markers for CIS- by an experienced pathologist. Results: CIS was detected in 5 individuals, whom all of them were unilateral and 2 of cases were whole testis. In this study we have prevalance of 0.69% (95% CI 0.21- 1.17%) in infertile males.Conclusion: This is the first study in Iran, in future we wish to be able to assess future trends in CIS incidence rates according to increasing incidence rate in industrial countries.