NUCL EAR DNA CONTENT AND DNA PLOIDY ANALYSIS IN BREAST CANCER
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Abstract:
To investigate the patterns of DNA ploidy and proliferating activity in breast cancer and relate them to other prognostic factors, paraffin blocks of 53 cases of breast carcinoma were studied. Cancer cells obtained by mechanical tissue disaggregation were examined for DNA content, ploidy and S-phase fraction. DNA assay was done using a CAS interactive image analyzing system. All of the cases showed high degrees of proliferation. The rate of aneuploidy was 77% in invasive breast carcinomas. S-phase fractions were correlated with the grades of the tumors (p<O.05). There was no statistically significant correlation between S-phase fractions and other prognostic factors this was also true about the pattern of ploidy and other prognostic factors.
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Journal title
volume 14 issue 3
pages 207- 209
publication date 2000-11
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