New Methods for Identifying Microorganisms as potential bioterrorism agents with Emphasis on Chromatography-Mass Spectrophotometry (GC-MS): Narrative Review

Today, with the development of microbiology, biotechnology, and cellular and molecular genetics, human knowledge of microorganisms has increased and the possibility of making biological weapons with pervasive effects has increased. On the other hand, bioterrorist events and the construction of laboratories and sites for the production of biological weapons in many developed and developing countries emphasize the need for rapid identification and determination of these bio-threatening agents. Accurate identification of such agents is important not only for the validation of a bioterrorism operation, but also for the timely implementation of appropriate measures for the biological agent to protect public health. As mentioned above, the biotheroism agents are very diverse and wide-ranging, hence it is always difficult and complex to identify these agents. Various methods have been introduced for detecting them. Some methods have been used for years, but some are still develoing. There are many problems in identifying and diagnosing bioterrorism agents, some of them are specific to one method, but some are common to all commonly used methods and developing methods. Therefore, this study aimed to investigate and review studies on the new methods of identifying microorganisms with bioterrorism potential from 2000 to 2020 as a review study.