New Approaches to Use Nanoparticles for Treatment of Colorectal Cancer; a Brief Review

Authors

  • Alireza Pasdar Department of Medical Genetic, Faculty of Medicine, Mashhad University, Mashhad, Iran|Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen, UK.
  • Amir Tajbakhsh Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Armin Imanparast Department of Medical physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Leila Hamzehzadeh Department of Medical Genetic, Faculty of Medicine, Mashhad University, Mashhad, Iran
  • Mahdi Rezaee Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. Although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. On the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (CRC) as the drug molecule does not reach the target site with an effective concentration. A major challenge in cancer therapy is to destroy tumor cells without harming the normal tissue. To overcome this problem scientists are trying to use nanoparticles to directly target cancer cells for a more effective treatment and reduced toxicity. Different nanoparticles such as: liposomes, polymeric nanoparticles, dendrimers, and silica have been developed to carry a variety of anticancer agents including: cytotoxic drugs, chemo modulators, siRNA and antiangiogenic agents. This review discusses various treatments for colon cancer and the potential use of nanoparticles which facilitate targeting of cancer cells. The outlook for new treatment strategies in CRC management is also underlined.

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Journal title

volume 1  issue 2

pages  59- 68

publication date 2016-10-01

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