Neonatal Purpura Fulminans

Authors

  • Reza Gharaee Department of pediatrics, Fellow of neonatology, Mashhad University of Medical Sciences , Mashhad, Iran
  • Reza Saeidi Department of pediatrics, Associate Professor of Neonatology, Mashhad University of Medical Sciences,Mashhad, Iran
  • Zohreh Nobakht Rheumatologist, Mashhad University of Medical Sciences , Mashhad, Iran
Abstract:

Neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. It manifests as DIC and extensive subcutaneous thrombosis. The condition is often fatal unless there is prompt diagnosis, and judicious therapy. The most important causes of this condition are infections and congenital deficiency of anticoagulant proteins C and S.In the case of PC (protein C) deficiency,the management includes an acute phase of replacement therapy with fresh frozen plasma (FFP) or protein C concentrate and a maintenance therapy that includes anticoagulation with Warfarin or low molecular weight heparin. Here we report a case of neonatal purpura fulminans due to suspected protein C deficiency.

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Journal title

volume 5  issue 1

pages  34- 37

publication date 2014-04-01

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