Morphometrical Evaluation of Corpus Callosum Using Mid-Sagittal Brain MRI Images in Patients With Relapsing-Remitting Multiple Sclerosis Referred to Besat Hospital in Hamadan from April 2011 To April 2021; A Retrospective Study
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Abstract:
Introduction: Corpus callosum (CC) as an intracranial organ is located in midline of cerebrum communicating both right and left hemispheres. CC undergoes morphological changes in multiple sclerosis (MS). Since the morphometrical changes of organs are directly associated with geographical regions, thus the aim of this study was to investigate the morphological alteration of CC in patients with relapsing-remitting MS in Hamadan (Iran) in a retrospective study from April 2011 to April 2021. Materials and Methods: Following conduction of inclusion and exclusion criteria, respectively 54 and 128 Brain MRI images of RRMS patients and healthy individuals were examined morphologically using PmsDICOMViewer software. Two main morphological indices of area (mm2) and longitudinal (mm) parameters were examined in midsagittal sections of Brain MRI images, including the area of CC (ACC) and associated segments, length of CC (LCC) and height of CC (HCC). Finally, the data were analysed by SPSS software (v. 19). P<0.05 was considered as significancy level and data were presented as mean±SEM. Results: Following MS onset, total area of CC (ACC) was decreased significantly (p<0.05) in MS patients than control. Also, the area of rosterum/genu (ARG) and area of anterior half midbody of CC (AAMB) showed significant (p<0.05) incremental and decrimental trends, respectively. In other indices, no significant (p>0.05) differences were detected. Conclusion: Morphometrical measurements of CC are associated with the presence of MS. By the assessment of the anterior half of CC in brain MRI images (ARG and AAMB), the diagnosis of MS can be occurred. Thus, the results of investigation can be proposed as criteria for radiological confirmation of MS diseaese.
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volume 19 issue None
pages 0- 0
publication date 2022-02
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