Low Prevalence of Borna Disease Virus RNA in Patients with Bipolar Major Depression and Schizophrenia in North of Iran

Authors

Abstract:

Background and Aims: Borna disease virus (BDV) is well known as a neurotropic virus, however, its role in human neurological diseases such as schizophrenia and bipolar disorder is still unclear. In this study, we aimed to investigate the BDV genome in such patients in Golestan province, North of Iran. Materials and Methods: RNA was extracted from peripheral blood mononuclear cells (PBMCs) from 250 people (125 patients with bipolar disorder (94.5%) and schizophrenia (3.1%) and 125 sex and age-matched healthy blood donors). Demographic information was collected through a questionnaire. RNA-driven cDNA was used for further BDV P40 genome tracking by Polymerase Chain Reaction (PCR). Results: Only one sample (1/125; 0.8%) of a female patient with bipolar disorder found to be positive for BDV P40. No significant family history of the disease found in both groups of patients. Seven patients with bipolar depression disorder (5.5%) had a history of animal contact. Conclusions: No BDV genome has been detected in the blood samples of the patients admitted to the hospital section of psychiatry in Gorgan city. Despite other genetic and environmental factors involved in psychiatric disorders, the serological study will give us a better insight of BDV prevalence in the region.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Multi-factorial Etiology of Bipolar Disorder and Schizophrenia in Iran: No Evidence of Borna Disease Virus Genome

ABSTRACT             Background and Objectives: Psychiatric disorders such as schizophrenia and bipolar disorder pose a high burden among the general population. Etiological factor(s) of such disorders remain unknown. Borna disease virus (BDV) is a neurotropic virus that has been suggested as an etiological agent for psychiatric disorder...

full text

No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran

Background and Objectives Viruses have been suggested as one of the risk factors for psychiatric disorders. Among infectious agents Borna disease virus (BDV) has been known as a neurotropic virus which is able to cause neurological disorders in different animals. Recently there were controversial findings about BDV association with pathogenesis of human psychotic disorders. Materials and Meth...

full text

faculty of psychology and social sciences group of anthropology master thesis in major of anthropology

چکیده پایان نامه (شامل خلاصه، اهداف، روش های اجرا و نتایج به دست آمده): کار جمع آوری گو یش های محلی در سال های اخیر شتاب امیدوار کننده ای به خود گرفته است. شاید از بارزترین اهداف جمع آوری گویش های مختلف، ثبت و ضبط آن، جلوگیری از نابودی و مهمتر از همه حل مشکلات دستوری زبان رسمی باشد. دقت در فرآیند های زبانی گویش های محلی نوع ارتباط مردم نواحی مختلف با پیرامون نشان را به ما نشان خواهد داد. از س...

role of cultural iran in promotion of multilaieralism in central asia and caucasus

cultural iran is a scope that is more extended than the political territories of iran as a political unit. this concept means that cultural geography(mehdi moghanlo-1383-1) of iran is greater than its political geography which, according to history, has a long history extending west-east from kandahar to the euphrates and north-south from the persian gulf to the caucasus including transoxiana a...

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 11  issue None

pages  8- 13

publication date 2017-06

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023