LITHIUM PERCHLORATE MEDIATED AMINATION REACTION OF ALDEHYDES: A NOVEL METHOD FOR SYNTHESIS OF N, N-DIALKYL-p-SILYLATED AMINES*
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Abstract:
P-Silylated N,N-dialkyl amines (5) were easily synthesized in good to excellent yield from aldehydes (1), trimethylsilyldialkylamines (2), and trimethylsilylmethylmagnesium chloride (4) in the presence of 5 M lithium perchlorate solution in diethyl ether. The reaction Of (2) with aldehyde proceeded smoothly in the LiCI0 , to give the imimum salt (3). Addition of trimethylsilylmethylrnagnesium chloride (4) gave the desired product
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lithium perchlorate mediated amination reaction of aldehydes: a novel method for synthesis of n, n-dialkyl-p-silylated amines*
p-silylated n,n-dialkyl amines (5) were easily synthesized in good to excellent yield from aldehydes (1), trimethylsilyldialkylamines (2), and trimethylsilylmethylmagnesium chloride (4) in the presence of 5 m lithium perchlorate solution in diethyl ether. the reaction of (2) with aldehyde proceeded smoothly in the lici0 , to give the imimum salt (3). addition of trimethylsilylmethylrnagnesium c...
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15 صفحه اولProtecting-group-free synthesis of amines: synthesis of primary amines from aldehydes via reductive amination.
New methodology for the protecting-group-free synthesis of primary amines is presented. By optimizing the metal hydride/ammonia mediated reductive amination of aldehydes and hemiacetals, primary amines were selectively prepared with no or minimal formation of the usual secondary and tertiary amine byproduct. The methodology was performed on a range of functionalized aldehyde substrates, includi...
full text-Solid Lithium Perchlorate, a Highly Efficient and Chemoselective Catalyst for the Acetalyzation of Aldehydes
-A simple, efficient, and general method has been developed for the chemoselective acetalization of aldehydes with 1,3-propanediol, 1,2-ethanediol and trimethyl orthoformate in the presence of solid lithium perchlorate under solvent-free conditions. Both cyclic and acyclic acetals of aldehydes were obtained under environmentally benign conditions in good to excellent yields.
full textnano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
چکیده ندارد.
-solid lithium perchlorate, a highly efficient and chemoselective catalyst for the acetalyzation of aldehydes
-a simple, efficient, and general method has been developed for the chemoselective acetalization of aldehydes with 1,3-propanediol, 1,2-ethanediol and trimethyl orthoformate in the presence of solid lithium perchlorate under solvent-free conditions. both cyclic and acyclic acetals of aldehydes were obtained under environmentally benign conditions in good to excellent yields.
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Journal title
volume 6 issue 3
pages -
publication date 1995-08-01
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