Intraarticular Administration of Tranexamic Acid Following Total Knee Arthroplasty: A Case-control Study
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Abstract:
Background: Tranexamic acid (TXA) has received extensive attention in management of blood loss in orthopedic surgeries. However, the ideal method of TXA administration is still controversial. This study aims to determine whether intraarticular injection of TXA reduces blood loss after total knee arthroplasty (TKA). Methods: Through a retrospective case-control study consecutive TKA patients receiving intraarticular TXA (Case group) were compared with similar patients undergoing TKA using traditional blood management strategy (Control group). Hemoglobin levels (Hb) before and after the surgery, need for transfusion, and reoperation due to massive blood loss were compared between the two groups. Results: Fifty TXA patients were compared with 50 patients of the control group. There was no significant difference between the two groups in terms of age, gender, and preoperative Hb. Postoperative blood loss and transfusion rate were significantly reducedin TXA patients compared to the control group (P
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intraarticular administration of tranexamic acid following total knee arthroplasty: a case-control study
background: tranexamic acid (txa) has received extensive attention in management of blood loss in orthopedic surgeries. however, the ideal method of txa administration is still controversial. this study aims to determine whether intraarticular injection of txa reduces blood loss after total knee arthroplasty (tka). methods: through a retrospective case-control study consecutive tka patients...
full textIntraarticular Administration of Tranexamic Acid Following Total Knee Arthroplasty: A Case-control Study.
BACKGROUND Tranexamic acid (TXA) has received extensive attention in management of blood loss in orthopedic surgeries. However, the ideal method of TXA administration is still controversial. This study aims to determine whether intraarticular injection of TXA reduces blood loss after total knee arthroplasty (TKA). METHODS Through a retrospective case-control study consecutive TKA patients rec...
full textTranexamic Acid Administration in Total Knee Arthroplasty Without Tourniquet
This open-access article is published and distributed under the Creative Commons Attribution NonCommercial No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article witho...
full textWhich Route of Tranexamic Acid Administration is More Effective to Reduce Blood Loss Following Total Knee Arthroplasty?
Background: The most appropriate route of tranexamic acid administration is controversial. In the current study, we compared the efficacy of intravenous (IV) and topical intra-articular tranexamic acid in reducing blood loss and transfusion rate in patients who underwent primary total knee arthroplasty. Methods: One hundred twenty 120 patients were scheduled to undergo primary total knee arth...
full textTranexamic Acid and Total Knee Arthroplasty
Total knee arthroplasty (TKA) is one of the most commonly performed elective orthopaedic procedures in the United States [1]. By 2030, the number is estimated to grow by 673% to 3.48 million TKAs performed a year [1]. TKA provides significant pain relief and improvement in quality of life [2]. However TKA surgery is not without complications. Of note is the risk of bleeding and requirement for ...
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Journal title
volume 2 issue 3
pages 141- 145
publication date 2014-09-01
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