Influence of Additives on Fabrication and Release from Protein Loaded Microparticles
Authors
Abstract:
The purpose of this study was to investigate the effect of additives, poly(ethylene glycol) (PEG) 1450, poloxamer 407, polyvinyl alcohol (PVA) and sodium chloride in order to improve physico-chemical characteristics, encapsulation efficiency and in vitro release of bovine serum albumin, form poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles prepared by the w/o/w solvent evaporation method. The addition of PEG 1450 and 0.05 M NaCl changed the surface characteristics of microparticles and also affected the encapsulation efficiency and burst release of protein. The effect of surfactants: polyvinyl alcohol and poloxamer 407 used in the outer water phase was investigated. The surfactant/PLGA mass ratio played an important role in the preparation procedure of the particles. This ratio was found to be approximately 0.5 for PVA and 5 for poloxamer 407 in order to achieve microparticles with narrow size distribution (70%).
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Journal title
volume 8 issue 3
pages 171- 179
publication date 2012-07-01
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