In vivo Toxicity Investigation of Magnesium Oxide Nanoparticles in Rat for Environmental and Biomedical Applications
Authors
Abstract:
Background: Magnesium oxide nanoparticles are characterized with a wide variety of applications and are mass-produced throughout the world. However, questions remain regarding their safety. There has been paucity of toxicology research on their side effects, especially under in vivo conditions. Objectives: The present paper aims at evaluating the toxicity of administering 10-15 nm magnesium oxide nanoparticles to Wistar rat under in vivo conditions. In addition, hematology, biochemistry, and histopathology of the rats are examined at various concentrations (62.5-125-250-500 µg.mL-1) over 28-days period. Materials and Methods: In this study, 35 male Wistar rats were randomly divided into five groups, comprising one control group and four experimental groups, assigned to various doses of MgO nanoparticles by intraperitoneal injection. Eventually, blood samples were collected, and all animals were sacrificed for liver and kidney tissue investigation. Results: The findings showed that high concentrations of Magnesium oxide nanoparticles (250 and 500 µg.mL-1) significantly increased white blood cells, red blood cells, hemoglobin, and hematocrit compared with the control group (P < 0.05). Moreover, the nanoparticles elevated the levels of aspartate aminotransferase and alkaline phosphatase, whereas no significant difference in levels of alanine aminotransferase, gamma-glutamyl transpeptidase, urea, and creatinine were recorded in comparison with the control group (P < 0.05). Histopathological examinations in the rat's liver showed proliferation of bile ductules, congestion in some regions of the liver sinusoids, and apoptotic cells (probably) in high-dose groups, but no histological changes were found in the kidney functions. Conclusions: The results from the present study showed that the magnesium oxide nanoparticles in concentrations lower than 250 µg.mL-1 are safe for desired applications.
similar resources
Preparation and characterization of PEG/Dextran coated superparamagnetic Iron Oxide (Fe3O4) nanoparticles for biomedical applications
Recent progress in nanotechnology and electrochemical methods can be applied to fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. Here we appliedcathodic electrochemical deposition (CED) as an efficient and effective tactic for synthesisand double coating of surface of superparamagnetic iron oxide nanoparticles (SPIONs). In first step, bare Fe3O4 n...
full textPreparation and characterization of PEG/Dextran coated superparamagnetic Iron Oxide (Fe3O4) nanoparticles for biomedical applications
Recent progress in nanotechnology and electrochemical methods can be applied to fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. Here we appliedcathodic electrochemical deposition (CED) as an efficient and effective tactic for synthesisand double coating of surface of superparamagnetic iron oxide nanoparticles (SPIONs). In first step, bare Fe3O4 n...
full textthe investigation of research articles in applied linguistics: convergence and divergence in iranian elt context
چکیده ندارد.
preparation and characterization of peg/dextran coated superparamagnetic iron oxide (fe3o4) nanoparticles for biomedical applications
recent progress in nanotechnology and electrochemical methods can be applied to fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. here we appliedcathodic electrochemical deposition (ced) as an efficient and effective tactic for synthesisand double coating of surface of superparamagnetic iron oxide nanoparticles (spions). in first step, bare fe3o4 n...
full textthe effect of oxytetracycline on serum calcium, phosphorus and magnesium in cattle
نتایج این مطالعه نشان می دهد که مقدار کلسیم (یونیزه و تام)، منیزیم و فسفر به طور معنی داری تغییر پیدا کرد به جزء مقدار کلسیم تام و منیزیم در روش داخل عضلانی که تغییر معنی داری نداشته است. بر اساس نتایج این مطالعه می توان نتیجه گیری کرد که اکسی تتراساکلین بر روی مقادیر سرمی کلسیم و منیزیم تأثیر می گذارد باید مقدار این کاتیون ها در بیماران، در هنگامی که اکسی تتراسایکلین استفاده می شود مورد توجه ق...
15 صفحه اولMy Resources
Journal title
volume 17 issue 1
pages 1- 9
publication date 2019-02-01
By following a journal you will be notified via email when a new issue of this journal is published.
Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023