In Vitro behavior of mechanically activated nanosized Si-Mg-doped fluorapatite

Authors

  • A. Monshi Biomaterials Research Group, Department of Materia, Isfahan University of Technology, Isfahan, 8415683
  • Ali Akbar Sharifnabi Biomaterials group, Department of Metallurgy and M, Iran University of Science and Technology, Tehran,
  • Batool Hashemibeni Department of Anatomical Sciences and Molecular Bi, Isfahan University of Medical Sciences, Isfahan 81
  • M. H. Fathi Biomaterials Research Group, Department of Materia, isfahan university of technology
  • Vajihosadat Mortazavi Torabinejad Dental Research Center, Department of, School of Dentistry, Isfahan University of Medical
Abstract:

Hydroxyapatite (HA) is perhaps the most attractive material for bone repair, replacement and regeneration, due to its chemical composition and crystallographic structure which are similar to those of natural bone mineral. However, replacement of various elements and compounds in HA, could improve biological properties of this material. The aim of this study was preparation, characterization and bioactivity evaluation of silicon and magnesium co-doped fluorapatite (Si-Mg-FA). Structural characterizations of synthesized powder were performed using X-ray diffraction (XRD) analysis; Fourier transformed infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) techniques. In vitro bioactivity was evaluated in simulated body fluid (SBF) at 37˚C for up to 28 days. Cell viability and cell attachment were studied by MTT assay and scanning electron microscopy (SEM).  The results showed that nanosized (~40nm) single-phase Si-Mg-FA powder was synthesized after 12 h of ball milling. In vitro examinations revealed the amount of bone-like apatite precipitated on Si-Mg-FA nanopowder was significantly higher than FA. The cell culture medium containing Si-Mg-FA showed more cell proliferation and cell viability than FA.  It could be concluded that doping Si and Mg into FA improves the bioactivity and cell viability, therefore, has a good potential to be used as bone substitution material.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Synthesis and in vitro antibacterial study of dihydropyrano[3,2-c]chromene derivatives by nano fluoro apatite doped with Mg and Si as a cooperative catalyst

One of the important Multi-component reaction (MCRs) is the synthesis of dihydropyrano chromene derivatives by one-pot reaction. In this research, an inexpensive and effective one pot three component procedure with good yields for the synthesis of dihydro pyrano chromenes is reported. In this method, the synthesis of pyrano chromene derivatives was followed by using 4-hydroxycoumarin, malononit...

full text

HPHT Diamond Crystallization in the Mg-Si-C System: Effect of Mg/Si Composition

Crystallization of diamond in the Mg-Si-C system has been studied at 7.5 GPa and 1800 ◦C with the Mg-Si compositions spanning the range from Mg-C to Si-C end-systems. It is found that as Si content of the system increases from 0 to 2 wt %, the degree of the graphite-to-diamond conversion increases from about 50 to 100% and remains at about this level up to 20 wt % Si. A further increase in Si c...

full text

Mechanically Activated Combustion Synthesis of B4C-TiB2 Nanocomposite Powder

Boron carbide is one of the hardest materials. The combustion method was used to synthesize B4C-TiB2 nanocomposite powder in a B2O3-Mg-TiO2-C system. An experimental study of the formation of B4C–TiB2 nanoparticles was conducted in the thermal explosion mode. A mixture of B2O3:TiO2:Mg:C at a molecular ratio of 3:1:12:1 was chosen to obtain the B4C–TiB2. This powder mixture was milled for differ...

full text

In Vitro Degradation Behavior of Ternary Mg-Zn-Se and Mg-Zn-Cu Alloys as Biomaterials.

In this study, the corrosion behavior of Mg-Zn-Se and Mg-Zn-Cu alloys was investigated to evaluate their corrosion behavior related to use as implantable biomaterials. The corrosion behavior of these alloys and a commercially available Mg-Zn alloy were examined using static solution electrochemical testing, dynamic solution gravimetric testing, ion leaching testing, and microscopic evaluation. ...

full text

Mg-Free Precursors for the Synthesis of Pure Phase Si-Doped α-Ca3(PO4)2

On this paper, methods to obtain Mg-free reagents for synthesizing pure phase Sistabilized α-TCP were established. The Mg contents of synthesized reagents were considerably lower than those in commercially available reactants. Pure Si-doped (2.5 at.-% of P by Si substitution) α-TCP was obtained by solid state reaction from synthetic reagents at temperature as low as 1200°C. When commercial reag...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 2  issue 3

pages  5- 11

publication date 2016-08-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023