IN TRAOPERATIVE RADIATION THERAPY FOR GASTRIC ADENOCARCINOMA

Authors

  • AC SAYAG
  • B SADEGHl-LOOYEH From the Departments of Digestive Surgery and Radiotherapy, Centre Hospitalier Univesitaire Lyon Sud, 69495, Pierre Benite Cedex, France.
  • FN GILLY
  • G BRAILLON
  • I SENTENAC
  • JB GRIOT
  • JP GERARD
  • P ROMESTAING
  • PY CARRY
Abstract:

Intraoperative radiation therapy (IORT) is a multidisciplinary approach in which residual tumors or tumor beds are directly irradiated during a surgical procedure. To evaluate its efficacy, from 1985, we conducted a prospective study including non-metastatic gastric adenocarcinoma treated by surgery, IORT (15 Grays) and postoperative external beam radiotherapy (44 Grays). Up to 1993, 51 cases of gastric adenocarcinoma (20 pN0 and 31 pN1-2) have been included in the study. Mortality and morbidity rates were not different from those of surgery alone. The overall 5 year survival rate was 59.1 %, and the pN1N2 5 year survival rate was 50.6'70. These promising results are comparable with those of Asian randomized studies which demonstrate the possible value of IORT in the treatment of gastric adenocarcinoma.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

in traoperative radiation therapy for gastric adenocarcinoma

intraoperative radiation therapy (iort) is a multidisciplinary approach in which residual tumors or tumor beds are directly irradiated during a surgical procedure. to evaluate its efficacy, from 1985, we conducted a prospective study including non-metastatic gastric adenocarcinoma treated by surgery, iort (15 grays) and postoperative external beam radiotherapy (44 grays). up to 1993, 51 cases o...

full text

Orthovoltage intraoperative radiation therapy for pancreatic adenocarcinoma

PURPOSE To analyze the outcomes of patients from a single institution treated with surgery and orthovoltage intraoperative radiotherapy (IORT) for pancreatic adenocarcinoma. METHODS We retrospectively reviewed 23 consecutive patients from 1990-2001 treated with IORT to 23 discrete sites with median and mean follow up of 6.5 and 21 months, respectively. Most tumors were located in the head of ...

full text

Adjuvant chemo-radiation for gastric adenocarcinoma: an institutional experience

BACKGROUND Studies have shown that surgery alone is less than satisfactory in the management of early gastric cancer, with cure rates approaching 40%. The role of adjuvant therapy was indefinite until three large, randomized controlled trials showed the survival benefit of adjuvant therapy over surgery alone. Chemoradiation therapy has been criticized for its high toxicity. METHODS 24 patient...

full text

Multimodality Therapy of Localized Gastric Adenocarcinoma.

Surgical resection is the primary method of obtaining a potential cure for patients with gastric adenocarcinoma. However, chemotherapy or chemoradiotherapy offer significant improvement in survival over surgery alone. Much of the difficulty in deciding the optimal treatment strategy is choosing between perioperative chemotherapy or adjuvant chemoradiotherapy. Adding to the complexity is the pot...

full text

Gastric adenocarcinoma surgery and adjuvant therapy.

Gastric adenocarcinoma is one of the most common causes of death worldwide. Surgical resection remains the mainstay of therapy, offering the only chance for complete cure. Resection is based on the principles of obtaining adequate margins, with the extent of lymphadenectomy remaining controversial. Neoadjuvant and adjuvant therapies are used to reduce local recurrence and improve long-term surv...

full text

Transanal excision with radiation therapy for rectal adenocarcinoma.

OBJECTIVE To evaluate the efficacy of transanal excision (TAE) combined with radiotherapy for rectal adenocarcinoma, assess the ability of pretreatment endoscopic ultrasound (EUS) to predict failures, and determine the prognostic value of downstaging and complete pathological response. DESIGN Retrospective outcomes study. SETTING Radiation oncology clinic. PARTICIPANTS Thirty-eight patien...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 9  issue 3

pages  183- 187

publication date 1995-10

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023