I-35: Induction of Ovulation in Clomiphen Resistant
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Abstract:
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder in which chronic anovulation is a common feature despite the presence of multiple micro- structures in the ovaries. A growing body of evidence has suggested that serum hyperinsulinemia and as the result hyperandrogenemia contributes to the excess ovarian androgen secretion observed in women with PCOS. The standard therapy for anovulatory women with PCOS is oral administration of clomiphene citrate (CC). However, a significant proportion of women with PCOS fail to ovulate with the use of standard dosage of CC and are called CC-resistant PCOS. Treatment options including extended clomiphene protocol, clomiphene and dexamethasone combined therapy, insulin-sensitizing agents and /or aromatize inhibitors, as adjuvants to clomiphene citrate and gonadotropins and finally surgical management of PCOD has changed the treatment strategy. Although both standard and novel treatments were addressed in the present review, special attention was paid to the evidence in support of the introduction of glucocorticoids and aromatize inhibitors in the management of anovulatory women with CCresistant PCOS.
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Journal title
volume 5 issue Supplement Issue
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publication date 2011-09-01
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