HLA-DRBI ALLELE FREQUENCY IN MYAS THENIA GRAVIS PATIENTS FROM SOUTHERN IRAN
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Abstract:
HLA-DRB1 allele frequencies of 28 myasthenia gravis (MG) patients, residents of southern Iranian provinces, were studied using PCR-SSP method. The control group consisted of 100 healthy individuals of the same ethnic group. The allele HLA-DRB1 * 16 (RR= 2.04, p= 0.028) was found to be significantly increased in MG patients compared to the control group, whereas HLADRB1 * 15(RR= 0.17 p= 0.043) and HLA-DRB1 *07 (p= 0.036) were found to be significantly increased in the control group compared to the patients, and seem to be negatively associated with the disease.
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hla-drbi allele frequency in myas thenia gravis patients from southern iran
hla-drb1 allele frequencies of 28 myasthenia gravis (mg) patients, residents of southern iranian provinces, were studied using pcr-ssp method. the control group consisted of 100 healthy individuals of the same ethnic group. the allele hla-drb1 * 16 (rr= 2.04, p= 0.028) was found to be significantly increased in mg patients compared to the control group, whereas hladrb1 * 15(rr= 0.17 p= 0.043) a...
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full textAssociation of HLA-DQA1*0101/2 and DQB1*0502 with myasthenia gravis in southern Iranian patients.
BACKGROUND Myasthenia gravis is an autoimmune disorder of neuromuscular junction characterized by skeletal muscle weakness and fatigability. Different genes may control the induction and clinical presentation of this disease. Various HLA alleles are reported as predisposing or protective genetic elements in myasthenia gravis. OBJECTIVE The aim of this study was to investigate the probable ass...
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Journal title
volume 14 issue 3
pages 223- 225
publication date 2000-11
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