High Sensitivity C–Reactive Protein and Im-munoglobulin G against Chlamydia Pneumo-niae and Chlamydial Heat Shock Protein-60 in Ischemic Heart Disease

Authors

  • Ali Esmaeeli-Nadimi Department of Cardiology
  • Mehdi Shariati Department of Histology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Abstract:

Background: Inflammation and infectious agents such as Chlamydia pneumoniae have been associated with cardiovascular disease. Objective: To evaluate the serum high sensitivity C - reactive protein (hs-CRP) and antibodies against Chlamydia pneumoniae and Chlamydial heat shock protein-60 (Cp-HSP60) in patients with ischemic heart disease (IHD). Methods: 62 patients with IHD having either acute myocardial infarction (AMI; n=31) or unstable an-gina (UA; n=31) and 31 sex- and age- matched healthy subjects as a control group were en-rolled in this study. Serum samples of participants were tested for the presence of hs-CRP and antibodies against C. pneumoniae and Cp-HSP60 using ELISA method. Results: The sero-prevalence of anti-C. pneumoniae antibody in AMI group (93.5%) or UA group (90.3%) was significantly higher than the control group (61.3%; p

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high sensitivity c–reactive protein and im-munoglobulin g against chlamydia pneumo-niae and chlamydial heat shock protein-60 in ischemic heart disease

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Journal title

volume 5  issue 1

pages  51- 56

publication date 2008-03-01

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