Hereditary leiomyomatosis and renal cell carcinoma (HLRCC syndrome): a case report

Molecular Basis of Hereditary Leiomyomatosis and Renal Cell Cancer (hlrcc)

Hereditary leiomyomatosis and renal cell carcinoma syndrome: a case report and implications of early onset*

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant manifestation of cutaneous and uterine leiomyomas together with renal cancer due to autosomal dominant germline mutations of fumarate hydratase gene. A twenty-year-old female patient presented with type-II segmental piloleiomyoma and increased menstruation due to uterine leiomyomas, with a history of bilateral n...

A Case of Hereditary Leiomyomatosis and Renal Cell Carcinoma

A 49-year-old lady presented with multiple recurring painful lesions over her thighs, arms, and back. Past medical history included a left sided nephrectomy for renal cell carcinoma and a hysterectomy for multiple uterine fibroids (leiomyomas). Histopathological examination revealed changes consistent with pilar leiomyomas. Gene mutation analysis confirmed a diagnosis of hereditary leiomyomatos...

Hereditary leiomyomatosis and renal cell carcinoma

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal-dominant hereditary syndrome, which is caused by germline mutations in the FH gene that encodes the tricarboxylic acid cycle enzyme fumarate hydratase (FH). HLRCC patients are predisposed to develop cutaneous leiomyomas, multiple, symptomatic uterine fibroids in young women resulting in early hysterectomies, and early on...

Post-transplant diagnosis of hereditary leiomyomatosis and renal cell carcinoma syndrome in a kidney donor

Program in Dermatopathology, Department of Pathology, Brigham andWomen’s Hospital, Harvard Medical School, Boston, MA, USA, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Division of Dermatopathology, Department of Pathology, Tufts University School of Medicine, Boston, MA, USA and Department of Dermatology, Brigham andWomen’s Hospital, Harva...

Treatment of cutaneous leiomyomas with 5% lidocaine patches in a patient with hereditary leiomyomatosis and renal cell cancer (Reed syndrome)

HLRCC: hereditary leiomyomatosis and renal cell cancer INTRODUCTION Hereditary leiomyomatosis and renal cell cancer (HLRCC) (formerly known as Reed syndrome, multiple cutaneous and uterine leiomyomatosis, leiomyomatosis cutis et uteri, and multiple leiomyomatosis) is an autosomal dominant syndrome comprising cutaneous leiomyomas, uterine leiomyomas, or renal tumors. The cutaneous leiomyomas of ...