HER-2/neu Marker Examination using Immunohistochemical Method in Patients Suffering from Gastric Adenocarcinoma

Authors

  • Kourosh Movagharnejad Department of pathology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
  • Majid Sharbatdaran Department of pathology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
  • Mehrdad Kashifard Department of Internal medicine , Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
  • Sadegh Sedaghat Department of Hematology and Oncology, Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
  • Shahryar Shefaee Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
Abstract:

Gastric adenocarcinoma is the second leading cause of death due to cancer in the world and in advanced stages the prognosis is poor with current therapies. Over-expression of HER-2/neu has been seen in several cancers such as gastric cancer and its expression is associated with poor prognosis. The aim of this study is to evaluate the over-expression of HER-2/neu in gastric biopsy samples of patients with gastric carcinoma diagnosis and to evaluate its probable relationship with clinical and pathological findings. The over-expression of HER-2/neu was examined retrospectively by immunohistochemistry method in 60 paraffin embedded samples collected in Babol, Iran, between 2010 and 2011. The over-expression of HER-2/neu has been observed in 6 patients (10%) and this over-expression was greater in the intestinal type of gastric adenocarcinoma than the diffuse type (12% vs. 6%) however, no statistically significant correlation between HER-2/neu expression and subtype, degree of differentiation, tumor type and age was observed. This over-expression was greater in differentiated types than undifferentiated types (18% vs. 5%).

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Journal title

volume 2  issue None

pages  199- 203

publication date 2013-09

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