Gut Microbiota and Chronic Hepatitis B and C Viruses-Induced Cirrhosis

Authors

  • Ahmadi Badi, Sara PhD in Microbiology, Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran. Tehran, Iran
  • Bahramali, Golnaz Assistant Professor, Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran
  • Motahhary, Atiyyeh MSc in Biotechnology, Faculty of Biological Sciences, Islamic Azad University Urmia, Urmia, Iran
  • Rahimi, Pooneh Associate Professor, Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran
  • Siadat, Seyed Davar Professor, Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran
  • suri, Mohamad mehdi MSc Student in Biotechnology, Faculty of Biological Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran
  • zaheri birgani, Mohamad MSc Student in Biotechnology, Faculty of Biological Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran
Abstract:

Hepatitis B and C viruses are major public health problems. These viruses can chronically lead to liver disease such as fibrosis, cirrhosis, and hepatocellular carcinoma, which often increase mortality in these patients. According to previous studies, the liver is highly affected by changes in the microbiota of gastrointestinal tract and immune system damage caused by inflammation due to viral hepatitis. Significant advances have been made in identifying gastrointestinal microbiota in cirrhotic patients associated with viral hepatitis and its use in their prognosis and treatment in recent years. Unique bacterial profiles are observed in cirrhotic patients associated with viral hepatitis, including increased numbers of Streptococcus, Prevotella, Staphylococcus, and Enterococcus, as well as decreased numbers of Clostridium and Ruminococcus. The purpose of this review was to summarize and discuss the gastrointestinal microbiota profile in patients with chronic hepatitis B and C and its role in the progression of cirrhosis.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Mutations at Nucleotide 1762, 1764 and 1766 of Hepatitis B Virus X Gene in Patients with Chronic Hepatitis B and Hepatitis B-Related Cirrhosis

Abstract       Background and objective: Hepatitis B virus (HBV) is a DNA virus with high tendency toward hepatic tissue. There are currently about 3 million HBV-infected people and 350 to 400 million chronic carriers of this virus in the world. X protein plays a role in the over-expression of oncogenes, carcinogenicity of liver cells and overlaps with the basal co...

full text

Evaluation of miR-101 Level in Patients with Chronic Hepatitis B Virus Infection and Liver Cirrhosis

ABSTRACT        Background and Objective: MiRNAs are small RNAs that are expressed in most eukaryotes, and can regulate gene expression by attaching to the 3’ end of target mRNA. MicroRNA-101 (miR-101) post-transcriptional regulation is important for host-virus interactions. In addition, miR-101 has a tumor suppressive role in liver cancer and metastasis, an...

full text

Distribution of Genotypes of B and C Hepatitis Viruses in Guilan Province

Today, chronic viral hepatitis is considered as a public health problem in the world. Totally, 5% of the world population, especially in Asia and Africa suffer from this problem. The prevalence of acute hepatitis in America is 0.1-0.2 percent, 50% of those with hepatitis C (HCV) and 5-10% of them with hepatitis B (HCV) develop chronic hepatitis. Determining HBV and HCV genotypes is important to...

full text

Gut Microbiota and Neuropsychiatric Disorders

full text

Liver cirrhosis and hepatocellular carcinoma in Mexico: impact of chronic infection by hepatitis viruses B and C.

full text

Cirrhosis, bile acids and gut microbiota

A picture is now starting to emerge regarding the liver-bile acid-microbiome axis. Increasing levels of the primary bile acid cholic acid (CA) causes a dramatic shift toward the Firmicutes, particularly Clostridium cluster XIVa and increasing production of the harmful secondary bile acid deoxycholic acid (DCA). During progression of cirrhosis, the microbiome, both through their metabolism, cell...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 31  issue 193

pages  103- 112

publication date 2021-01

{@ msg @}

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023