Frequency of Smear-Negative Tuberculosis in Northwest Iran

Authors

  • Behroz Mahdavi Poor Department of Laboratory Science, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran; and Department of Medical Parasitology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
  • Jalil Rashedi Department of Laboratory Science, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran; and Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;
  • Mahya Pourostadi Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Maral Hariri-Akbari Adjunct Lecturer, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Asgharzadeh Biotechnology Research Center and Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:

Background: Microscopic smear examination is the most common test in tuberculosis (TB) detection. It is, however, not strong enough to identify TB in the majority of afflicted individuals; thus, a significant number of TB patients are smear negative and capable of transmitting the infection. The aim of this study was to evaluate the rate of smear-negative TB in northwest Iran.Methods: In this cross-sectional study, 329 TB-confirmed patients were evaluated through culture up to March 1, 2015, in northwest Iran. The demographic and clinical features of the smear-negative and smear-positive TB patients were compared. The χ2 test was used to compare the frequency of the variables. All the statistical analyses were conducted using SPSS, version 16 (Chicago, IL, USA).Results: Seventy-five cases were smear negative and 254 were smear positive. Smokers, asthmatics, and extra-pulmonary TB patients were primarily among the smear-negative cases. The rate of mortality was also relatively higher among the smear-negative TB patients.Conclusion: Totally, 22.8% of the TB cases in northwest Iran were smear negative, with a relatively higher rate of mortality than those with positive smears. A delay in these patients’ return to TB diagnosis and treatment centers increases the chance of transmission to others. This is a very sensitive issue in centers where there is no equipment for TB cultivation. Thus, it is essential to equip centers without TB cultivation facilities and to use appropriate diagnostic techniques in centers with those facilities to help rapidly detect smear-negative cases.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Sputum Smear Negative pulmoNary tuberculoSiS

The objectives of this study were to evaluate the suitability of the TB-SA antibody test to diagnose tuberculosis in sputum smear negative (SS-) pulmonary tuberculosis (TB) patients and its applicability for monitoring treatment outcomes in these patients. This study was conducted in three counties/districts in Chongqing Municipality, Liaoning Province, China between June 2005 and June 2007. A ...

full text

The role of bronchoscopy in diagnosis of tuberculosis in patients with negative smear & culture

tuberculosis (TB) is a serious health problem in the world.in 1990 among 5.5 million population in the world,nearly 7.5 million new cases reported and 3 million  patients expired due to this problem.because early detectio of TB is very important ,we decided to evaluate the role of fiberoptic bronchoscopy(FOB) in detection of TB in patients with negative smear and negative culture of sputum.in t...

full text

Smear-negative pulmonary tuberculosis in industrialized countries.

that repeatedly have proven this assumption to be false and a world literature replete with reports of the success of directly observed therapy, these centers contend that there is no firm evidence demonstrating that directly observed therapy is both effective and essential in the treatment of tuberculosis. It is time for physician organizations from all parts of the international community to ...

full text

Fibreoptic bronchoscopy in smear-negative pulmonary tuberculosis.

Fifty smear-negative pulmonary tuberculosis patients underwent fibreoptic bronchoscopy. Bronchial aspirate smears of twelve patients and post-bronchoscopic sputum smears of fourteen patients were positive for acid-fast bacilli (AFB). Bronchial biopsy provided the diagnosis in 9 out of 30 patients. Brush smears were positive in 28 patients, being the only positive sample in ten cases. A high yie...

full text

The role of bronchiL brushing through fiber-optic bronchoscopy in rapid diagnosis of sputum smear negative cases of pulmonary tuberculosis

  The aim of this study was to determine the ability of bronchial brushing in rapid diagnosis of pulmonary tuberculosis in patients with negative sputum smear.this retrospective study was performed on 188 patients who were suspected of pulmonary tuberculosis and had undergone fiberoptic bronchoscopy during the period of 1990 to 1996 in Kerman university No.1 . Although their history, physical ...

full text

Microscopic examination and smear negative pulmonary tuberculosis in Ethiopia

INTRODUCTION Tuberculosis causes illness among millions of people each year and ranks as the second leading cause of death from infectious disease worldwide. The aim of this study was to investigate the detection rate of microscopic examination and estimate risk of transmission of TB by smear negative pulmonary TB patients. METHODS A cross-sectional study and retrospective data analysis on TB...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 43  issue 3

pages  269- 275

publication date 2018-05-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023