Frequency of BK Polyoma Virus in Bladder Cancer

Authors

  • Hasan Jahanbakhsh-kotlar Faculty of Medicine, Mashhad University of Medical Sciences
  • Mahmoud-Reza Kalantari
  • Majid Khadem-Rezaiyan Clinical Research Development Unit, Mashhad University of Medical Sciences
  • Masoud Youssefi Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iranک Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Masoumeh Gharib Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences
  • Saeed Amel-Jamehdar Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Taban Javadzahed Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Tahmine Bakhshi Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Zahra Meshkat Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

The BK virus a member of the Polyomaviruses family was first isolated from the urine of the kidney recipient. Infection with this virus and infection usually occurs in childhood (5-9 years) but most of the time (90%) of sera are positive and without symptoms. Polyomaviruses including the BK virus have also been suggested to be a contributing factor to some cancers in humans such as brain tumors, bone tumors, Kaposi’s sarcoma, adrenal tumors, renal carcinoma, prostate cancer, urinary tumors, genital tumors and etc. however the topic still remains controversial. In this study, we report the presence of BK specific DNA sequences in bladder cancer by PCR and Nested PCR methods. Our study results confirmed the presence of BK in 13.7% of the samples.

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volume 14  issue None

pages  0- 0

publication date 2020-06

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