Fabrication and Characterization of Polycaprolactone – Zeolite Y Nanocomposite for Bone Tissue Engineering

Authors

  • Javadpour, J. Department of Materials and Metallurgical Engineering, Iran University of Science and Technology, Narmak, Tehran 16846-13114, Iran.
  • Kharaziha, M. Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
  • Rezaie, H.R. Department of Materials and Metallurgical Engineering, Iran University of Science and Technology, Narmak, Tehran 16846-13114, Iran.
  • Zakeri, N. Department of Materials and Metallurgical Engineering, Iran University of Science and Technology, Narmak, Tehran 16846-13114, Iran.
Abstract:

In recent years, nanoceramics have been used in scaffolds to emulate the nanocomposite with a three-dimensional structure of natural bone tissue. In this regard, polycaprolactone biopolymer is widely used as a scaffold in bone tissue engineering. The goal of this research is to produce porous scaffolds of polycaprolactone - zeolite biocomposite with suitable mechanical, bioactive and biological properties  for bone tissue engineering applications. The nanocomposite scaffolds were synthesized by solvent casting/particulate leaching and freeze-drying approaches. Microscopic investigations showed generation of pores with an average size of 200-400μm after addition of ceramic phase. Energy dispersive X-ray analysis confirmed uniform distribution of ceramic phase in polycaprolactone matrix. FTIR results determined the binding type of zeolite nanoparticles to the polycaprolactone matrix as physical bonding. The results of mechanical tests showed the increase in young’s modulus after addition of ceramic phase (from 0.04 to 0.3 and 3 to 7 MPa, respectively). The hydrophilicity of polycaprolactone increased after adding nanozeolite and more weight loss was observed for scaffold containing 20% zeolite (53.52 6 1.6%) with an increase in the rate of hydroxyapatite formation. The results showed that the prepared scaffolds have potential for cancellous bone tissue engineering application.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Electrospun biocompatible Gelatin-Chitosan/Polycaprolactone/Hydroxyapatite nanocomposite scaffold for bone tissue engineering

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

full text

Electrospun biocompatible Gelatin-Chitosan/Polycaprolactone/Hydroxyapatite nanocomposite scaffold for bone tissue engineering

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

full text

Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering

Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

full text

preparation, characterization and biological assessment of polycaprolactone/starch composites for bone tissue engineering applications

objective: biodegradable polycaprolactone/starch composites can be used for bone tissue engineering applications. the effect of the ratio of components on composite properties is of tremendous importance. methods: polycaprolactone/starch composite of 80/20 and 70/30 ratios were fabricated by dissolving them in chloroform followed by evaporation of the solvent. results: the composites were chara...

full text

fabrication and characterization of regenerated silk/bioglass composites for bone tissue engineering

objective: one of the major issues in bone tissue engineering is the design and fabrication of bioactive, bioresorbable porous 3d scaffolds capable of maintaining their structure and integrity over a predictable period of time. one such approach is the fabrication of composite scaffolds. methods: in this study we present fabrication and characterization of novel silk/bioglass-composite scaffold...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 39  issue 4

pages  77- 94

publication date 2021-02

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023