Extramedullary Hematopoiesis in a Patient with Transfusion Dependent Beta-Thalassemia Presenting with Cord Compression
Authors
Abstract:
Extramedullary hematopoiesis (EMH) is a physiological compensatory phenomenon occurring in many hemolytic anemias including thalassemia. Besides transfusion, radiotherapy, surgery or a combination of these modalities, hydroxyurea (HU) as an optimal treatment has been described occasionally. We described a case of beta-thalassemia major who has been on regular blood transfusion and developed EMH that was treated with HU combined with radiotherapy. EMH should also be considered in thalassemia major patients, although it is more common in non-transfusion dependent thalassemia patients. HU combined with low dose radiotherapy along with regular blood transfusion are suggested as good treatment options for patients with EMH.
similar resources
MR of extramedullary hematopoiesis causing cord compression in beta-thalassemia.
A 30-year-old woman presented with back pain, weakness and numbness in both lower extremities, and difficulty initiating voiding. The patient was diagnosed at age 3 with beta-thalassemia intermedia. Physical examination revealed frontal bossing, a prominent mandible, T 4-level tenderness, decreased strength, light touch, pin prick and temperature in both lower extremities, abdomen and back with...
full textextramedullary hematopoiesis presenting as a right adrenal mass in a patient with beta thalassemia
introduction extramedullary hematopoiesis in the kidney and adrenal are rarely reported in medical literature and are usually found as incidentaloma. it usually occurs in patients with hematologic disorder such as thalassemia. case presentation the patient was a 23-year-old iranian man with beta thalassemia who was admitted with a suprarenal mass. adrenal mass was detected by ultrasonography an...
full textExtramedullary Hematopoiesis Presenting as a Right Adrenal Mass in a Patient With Beta Thalassemia
INTRODUCTION Extramedullary hematopoiesis in the kidney and adrenal are rarely reported in medical literature and are usually found as incidentaloma. It usually occurs in patients with hematologic disorder such as thalassemia. CASE PRESENTATION The patient was a 23-year-old Iranian man with beta thalassemia who was admitted with a suprarenal mass. Adrenal mass was detected by ultrasonography ...
full textDiffuse Hepatic Calcifications in a Transfusion-Dependent Patient with Beta-Thalassemia: A Case Report
Hepatic calcification is usually associated with infectious, vascular, or neoplastic processes in the liver. We report the first case of beta-thalassemia major with isolated diffuse hepatic calcification in a 23 year old woman, who had been transfusion-dependent since the age of 6 months. She was referred to our center with a chief complaint of abdominal pain. Computed tomography scan of the ab...
full textCord Compression due to Extramedullary Hematopoiesis in an Adolescent with Known Beta Thalassemia Major.
We describe a 16 year-old male with β thalassemia major and gait disturbances that had not been given blood transfusions due to a severe childhood transfusion reaction. Thoracic spine MRI demonstrated hematopoietic marrow throughout the spine and epidural masses causing cord compression consistent with extramedullary hematopoiesis (EMH). After treatment with steroids, radiotherapy and monitored...
full textThalassemia, extramedullary hematopoiesis, and spinal cord compression: A case report
BACKGROUND Extramedullary hematopoiesis (EMH) refers to hematopoiesis outside of the medulla of the bone. Chronic anemia states such as thalassemia can cause hematopoietic tissue to expand in certain locations. We report a case of spinal cord compression due to recurrent spinal epidural EMH, which was treated with a combination of surgery and radiotherapy. Pakistan has one of the highest incide...
full textMy Resources
Journal title
volume 10 issue None
pages 28- 30
publication date 2018-03
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023