Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy
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expression and distribution of calcium-binding protein s100p in human placenta during pregnancy
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full textExpression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy
BACKGROUND S100P is a member of the S100 family of calcium-binding proteins, and it participates in pathophysiological events, such as tumor growth and invasion. Based on the striking similarities between trophoblast cells and tumor cells with regard to proliferative and invasive properties, we raised the question of whether and how S100P expresses in trophoblast cells during development. This ...
full textThe calcium-binding protein S100P in normal and malignant human tissues
BACKGROUND S100P is a Ca2+ binding protein overexpressed in a variety of cancers, and thus, has been considered a potential tumor biomarker. Very little has been studied about its normal expression and functions. METHODS We examined S100P expression in normal human tissues by quantitative reverse transcription polymerase chain reaction and immunohistochemistry. S100P protein expression was al...
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full textCa2+-binding protein of the human placenta
The Ca2+-binding protein (HCaBP) of the human placenta was studied with respect to its biochemical properties, tissue and cellular distribution, and possible involvement in placental Ca2+ transport. Optimal Ca2+ binding by the HCaBP occurs at pH7-8 and in I00mM-Na+ and 3mM-Ca2+. The HCaBP possesses at least 10 Ca2+-binding sites with a Kd of 5 x 10-6M ([Ca2+]). Highly specific rabbit-derived an...
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volume 8 issue 4
pages 445- 452
publication date 2015-02-01
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