Exploring the effect of intravenous lipid emulsion in acute methamphetamine toxicity

Authors

  • Ameneh Ghadiri Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Iran
  • Amir Hossein Jafarian Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • Farzin Hadizadeh Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Leila Etemad Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mahmoud Seifi Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Moshiri Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
  • Seyed Adel Moallem Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Objective(s): The increasing use of methamphetamine (METH) in the last decades has made it the second most abused drug. Advancs in the area of intravenous lipid emulsion (ILE) have led to its potential application in the treatment of poisoning. The present study aims to investigate the potential role of ILE as an antidote for acute METH poisoning. Materials and Methods: Two groups of six male rats were treated by METH (45 mg/kg), intraperitoneally. Five to seven min later, they received an infusion of 18.6 ml/kg ILE 20% through the tail vein or normal saline (NS). Locomotor and behavioral activity was assessed at different time after METH administration. Body temperature and survival rates were also evaluated. Brain and internal organs were then removed for histological examination and TUNEL assay. Results: ILE therapy for METH poisoning in rats could prevent rats mortalities and returned the METH-induced hyperthermia to normal rates (P

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Journal title

volume 20  issue 2

pages  138- 144

publication date 2017-02-01

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