Experimental study: experimental evaluation of phospholipid system containing doxorubicin HCL for use in chemotherapy

Authors

  • Baghiani, Morteza . Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Haghiralsadat, Fatemeh Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Majdizadeh, Mohammad Nano-Biotech Foresight Company Biotechnology Campus, Science & Technology Park of Yazd, Yazd, Iran
  • Moosavizadeh, Seyed-Mahmoud . Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Moosavizadeh, Syed-Mohammad . Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract:

Introdution: Common cancer treatment methods have many side effects. Therefore, the use of new methods for drug delivery to cancer cells is necessary. In the present study, nano formulations of lipid carriers containing doxorubicin have been synthesized and its physicochemical properties have been investigated. Methods: The present study was an experimental study. The liposomal systems were synthesized by the method of thin-film hydration and using Tween-20, cholesterol and soybean phosphatidylcholine. After loading Doxorubicin drug into the liposomes, physiochemical properties of nano-carriers were determined from the perspective of encapsulation efficiency, drug release profile under healthy and cancerous cells condition, hydrodynamic diameter, zeta potential, morphology and IR spectra. Results: The liposomal system had 132.9 nm in diameter, the encapsulation 93.74% and -38.73±0.18mV zeta potential. The maximum release of drug from the nano-carrier under conditions 37°C, pH=7.4 and 42°C, pH=5.4 and 37°C, pH=5.4 after 72 hours was 36.54% and 74.18% and 55.9% respectively. SEM and IR assessments revealed spherical morphology and the absence of chemical interaction between nano-carrier and drug. Conclusion: The result of this research indicates that the liposomal system, having the appropriate physiochemical properties, has not changed the chemical nature of drug and thus can be a suitable and semi-targeted carrier for doxorubicin.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

simulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water

abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...

The effect of cold hat use on chemotherapy-induced hair loss in breast cancer patients: An experimental study in Tehran

Background. Hair loss (alopecia) is a common side effect of chemotherapy drugs, imposing further psychological stress on the patient. Scalp cooling is a common method used to prevent chemotherapy-induced alopecia; however, the results are not conclusive. The present study aimed to investigate the effectiveness of using a cold cap during chemotherapy in preventing alopecia in women with breast c...

full text

Experimental study of doxorubicin interventional chemotherapy in the treatment of rabbit VX2 renal transplantation carcinoma.

OBJECTIVE This study aims to explore the effect of doxorubicin interventional chemotherapy on rabbit VX2 renal transplantation carcinoma and its mechanism. METHODS Thirty healthy New Zealand white rabbits were chosen to establish VX2 renal transplantation carcinoma models. The experimental rabbits were randomly divided into three groups with 10 rabbits in each group. The rabbits in the contro...

full text

study of cohesive devices in the textbook of english for the students of apsychology by rastegarpour

this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...

preparation and evaluation of poly (caprolactone fumarate) nanoparticles containing doxorubicin hcl

full text

Experimental Chemotherapy

the heart of all pharmacological inquiry and the hope of chemotherapy. According to Lasagna, although drug effects are generally viewed as an inevitable sequence of phenomena induced by a stimulus, i.e., by an active chemical, pharmacological variables such as route and dose are insufficiently specified and the problems of the personality, attitudes of subjects and experimenters, or the charact...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 26  issue 11

pages  945- 956

publication date 2019-03

{@ msg @}

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023