Experience with production and control of attenuated poliovirus (Subinstrains) in human diploid cells

When stationary cultures of human diploid cells in conventional Roux bottles were replaced by the development of cells in roller bottles, the yield of poliovirus, Sabin strains type 1 and 2, showed an increase of 0.5 to 1 log10. No significant difference was noticed in the yield of these viruses cultured in WI-38 and MRC-5 human diploid cells.

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Journal title

Archives of Razi Institute

volume 30 issue 1

pages 39- 50

publication date 1978-02-01

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