Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure

Authors

  • Dan Wang Division of physical education, General course Teaching Department, Weifang Medical University, Weifang 261053, Shandong Province, China
  • Kai Gao Medical Imaging Faculty, Weifang Medical University, Weifang 261053, Shandong Province, China
  • Li Wang Department of Physical Education, Shandong University, Weihai, Weihai 264209, Shandong Province, China
Abstract:

Objective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were randomly divided into sham operation group (Sham group), CHF model group, and CHF exercise group (Exercise-CHF group). Results: Our data showed that when compared to the Sham group, the left ventricular systolic pressure (LVSP), myocardial glycogen content, and expression levels of key components of AMP-activated protein kinase (AMPK) pathway were decreased significantly (P

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Journal title

volume 21  issue 8

pages  818- 823

publication date 2018-08-01

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