Evaluation of Pain Tolerance Threshold Following Anti TNF-α after Induction REM Sleep Deprivation in a Male Wistar Rat Model (In press)

Background and Aim: Tumor Necrose Factor-alpha (TNF-α) changes by REM sleep deprivation. Some believe that TNF-α is a biomarker in the deprivation of REM sleep. The patients with insomnia could be better after using Anti TNF-α or Infliximab (IFX), on the other hand, IFX effects on Patient Tolerance Threshold (PTT). Trying to manage the hospital inpatients’ pain is one of the common aims specially for intensive care unit patients. Methods and Materials: An experimental study with 72 male Wistar rats in 9 groups that each of groups include 8 rats and approved according to the ethics code in ethics committee of Tehran medical sciences university (CNS.Protocol-ICSS-940816). IFX was administered and it showed the time of the latency changed as PTT. Results: A significant difference between saline and IFX 0.2 mg/kg (F2 = 8.363, (P = <0.001)) in the time of latency observed. Conclusion: REM sleep deprivation effects on TNF-α and IFX change the PTT in a Wistar rat model. So, these findings could be considered complex for patients and must to manage.