Evaluation of L-arginine Effects on Refractory Seizures in Epileptic Patients

Authors

  • Farhad Iran Manesh Professor of Neurology, Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
  • Hasibeh Molla Mohammadi Medical Student, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  • Mahdi Ansari Professor of Pharmacology, Kerman University of Medical Sciences, Kerman, Iran
  • Sepideh Ebrahimi Medical Student, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Abstract:

Background:epilepsy is one of the common neurological disorders and approximately 0.5-1% of populations suffers from it. Unfortunately, despite of treatment by antiepileptic drugs, between 20-30% of patients cannot be controlled completely. There are a lot of supplementary therapies for this group of patients and in this study, L-arginine was used as an additional therapy in refractory epileptic patients. Methods: Two groups of epileptic patients (n=21) were selected randomly. Group 1 received lactose as a placebo, and group 2 received L-arginine (twofold of daily need) as a drug for three months. We used a standard questionnaire for evaluating the effect of L-arginine on the quality of life before and after the study. Results: we did not find significant change in the quality of life of patients after using L-arginine, but the epileptic attacks decreased in L-arginine group significantly. Conclusion: L-arginine therapy is safe and can decrease the rate of seizure attacks in refractory epileptic patients, and can be an alternative of ketogenic diets.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

[Epileptic seizures in multiple sclerosis patients].

Epileptic seizures were one of the clinical manifestations of multiple sclerosis in 12 out of the 800 patients studied. They were more frequent during the disease exacerbation and served as an indicator of the pathological process activity. The significance of immunological impairments in the genesis of these attacks is outlined.

full text

Coenzyme Q10 Insufficiency Contributes in Duration and Frequency of Seizures in Epileptic Patients

Purpose: Oxidative stress has recently emerged as a possible mechanism in pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and reactive oxygen species (ROS) production, however, the impact of CoQ10 on seizure characteristics in epileptic patients is not clear. Methods: The current study enrolled patients with the epilept...

full text

Effects of L-arginine cardioplegia on myocardium.

Infusion of L-arginine (a precursor of nitric oxide, NO) in cardioplegia was examined to test its effect on metabolism of myocardium after myocardial ischemia and reperfusion (IR). Twenty-eight patients undergoing valve replacement were involved and randomly divided into two groups: the control group (crystalloid cardioplegia) and the experimental group (crystalloid cardioplegia + L-arginine). ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 27  issue 3

pages  213- 221

publication date 2020-05-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023